DHBP dibromide
产品说明书
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同义名 : | Diheptylviologen dibromide |
| CAS号 : | 6159-05-3 | |
| 货号 : | A587221 | |
| 分子式 : | C24H38Br2N2 | |
| 纯度 : | 95% | |
| 分子量 : | 514.38 | |
| MDL号 : | MFCD00011997 | |
| 存储条件： |
Pure form Inert atmosphere, room temperature In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
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| 描述 | DHBP is an inhibitor for calcium release and a muscle relaxant. DHBP inhibited the calcium release induced by 2 mM caffeine and 2 micrograms ml-1 polylysine with an IC50 value of 5 micrograms ml-1 and 4 micrograms ml-1 respectively. DHBP inhibited [3H]-ryanodine binding in a dose-dependent manner with an IC50 of 2.5 micrograms ml-1 and 90-100% inhibition at 20-30 micrograms ml-1. 4. Muscle twitches elicited by direct electrical muscle stimulation and contractions induced by either 10 mM caffeine or 1 microM ryanodine were blocked by pretreatment with DHBP. DHBP blocks the calcium release from SR by direct interaction with the calcium release channel, also known as the ryanodine receptor[1]. Direct His-bundle pacing (DHBP) produces synchronous ventricular depolarization and improved cardiac function relative to apical pacing. Permanent DHBP is feasible in select patients who have chronic atrial fibrillation and dilated cardiomyopathy[2]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
1.94mL 0.39mL 0.19mL |
9.72mL 1.94mL 0.97mL |
19.44mL 3.89mL 1.94mL |
| 参考文献 |
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