Inauhzin
产品说明书
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同义名 : | INZ |
| CAS号 : | 309271-94-1 | |
| 货号 : | A586304 | |
| 分子式 : | C25H19N5OS2 | |
| 纯度 : | 99%+ | |
| 分子量 : | 469.58 | |
| MDL号 : | MFCD01819836 | |
| 存储条件： |
Pure form Sealed in dry, 2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
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| 靶点 |
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| 描述 | Inauhzin at a concentration of 10 µM elevates p53 levels comparably to actinomycin D at 10 nM and promotes p53-dependent cytotoxicity via its distinct functional groups in human lung carcinoma H460 cells. A lower concentration of Inauhzin (2 µM) enhances both the level and activity of p53, along with initiating p53-dependent apoptosis. It stabilizes p53, prevents its ubiquitylation, and increases p53 acetylation in H460 cells, specifically without affecting tubulin. This acetylation is impacted by the knockdown of SIRT1[1]. At doses up to 2 µM, Inauhzin markedly boosts the expression and activity of p53 in both HCT116p53+/+ and H460 cells in a dose-responsive manner. When combined with Nutlin-3, Inauhzin displays synergistic cytotoxic effects, particularly in cells with low sensitivity to Nutlin-3, and jointly they trigger p53-dependent apoptosis[2]. | ||
| 实验方案 | |||
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| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.13mL 0.43mL 0.21mL |
10.65mL 2.13mL 1.06mL |
21.30mL 4.26mL 2.13mL |
| 参考文献 |
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