Dipraglurant

产品说明书

Print
Chemical Structure| 872363-17-2 同义名 : ADX48621
CAS号 : 872363-17-2
货号 : A584643
分子式 : C16H12FN3
纯度 : 98%
分子量 : 265.29
MDL号 : MFCD18633187
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 Dipraglurant is a mGluR5 antagonists with IC50 of 0.021 μM.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.77mL

0.75mL

0.38mL

18.85mL

3.77mL

1.88mL

37.69mL

7.54mL

3.77mL
参考文献

[1]Tison F, Keywood C, et al. A Phase 2A Trial of the Novel mGluR5-Negative Allosteric Modulator Dipraglurant for Levodopa-Induced Dyskinesia in Parkinson's Disease. Mov Disord. 2016 Sep;31(9):1373-80.

[2]Bezard E, Pioli EY, et al. The mGluR5 negative allosteric modulator dipraglurant reduces dyskinesia in the MPTP macaque model. Mov Disord. 2014 Jul;29(8):1074-9.