同义名 :	-
	CAS号 :	20736-09-8
	货号 :	A584273
	分子式 :	C42H68O13
	纯度 :	98+%
	分子量 :	780.98
	MDL号 :	N/A
	存储条件：	Pure form Sealed in dry, 2-8°C In solvent -20°C:3-6个月-80°C:12个月
	溶解度 :	-
	动物实验配方：

生物活性

描述

Saikosaponin A (SSA), a main triterpenoid saponin component from Radix Bupleurum, has been revealed to have a variety of pharmacological activities. SSA can suppress angiogenesis and tumor growth by blocking the VEGFR2-mediated signaling pathway[3]. SSa (Saikosaponin A) inhibited IL-1β-induced PGE2 and NO production in a concentration-dependent manner. SSa also suppressed IL-1β-induced MMP1, MMP3, and MMP13 production. Furthermore, SSa significantly attenuated IL-1β-induced phosphorylation levels of NF-κB p65 and IκBα. SSa also up-regulated the expression of LXRα. The inhibition of SSa on PGE2, NO, MMP1, MMP3, and MMP13 production were reversed by LXRα siRNA or GGPP, the inhibitor of LXRα[4]. SSa played a critical anti-inflammatory effect through inhibition of NF-κB and NLRP3 signaling pathways and protected against LPS-induced ALI(acute lung injury)[5]. Saikosaponin A had protective effects against DSS (dextran sulfate sodium)-induced colitis. Saikosaponin A protected DSS-induced colitis through inhibiting inflammatory response[6].

实验方案
	1mg	5mg	10mg
1 mM 5 mM 10 mM	1.28mL 0.26mL 0.13mL	6.40mL 1.28mL 0.64mL	12.80mL 2.56mL 1.28mL

参考文献

[1]Zhou C, Liu W, et al. Saikosaponin a inhibits RANKL-induced osteoclastogenesis by suppressing NF-κB and MAPK pathways. Int Immunopharmacol. 2015 Mar;25(1):49-54. [2]Zhu J, Luo C, et al. Saikosaponin A mediates the inflammatory response by inhibiting the MAPK and NF-κB pathways in LPS-stimulated RAW 264.7 cells. Exp Ther Med. 2013 May;5(5):1345-1350. [3]Zhang P, Lai X, Zhu MH, Long M, Liu XL, Wang ZX, Zhang Y, Guo RJ, Dong J, Lu Q, Sun P, Fang C, Zhao M. Saikosaponin A, a Triterpene Saponin, Suppresses Angiogenesis and Tumor Growth by Blocking VEGFR2-Mediated Signaling Pathway. Front Pharmacol. 2021 Oct 29;12:713200 [4]Gao H, Song Y, Li D, Feng W, Liu J. Saikosaponin A inhibits IL-1β-induced inflammatory mediators in human osteoarthritis chondrocytes by activating LXRα. Oncotarget. 2017 Sep 30;8(51):88941-88950 [5]Du ZA, Sun MN, Hu ZS. Saikosaponin a Ameliorates LPS-Induced Acute Lung Injury in Mice. Inflammation. 2018 Feb;41(1):193-198 [6]Zhou F, Wang N, Yang L, Zhang LC, Meng LJ, Xia YC. Saikosaponin A protects against dextran sulfate sodium-induced colitis in mice. Int Immunopharmacol. 2019 Jul;72:454-458