KS176
产品说明书
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同义名 : | - |
| CAS号 : | 1253452-78-6 | |
| 货号 : | A578694 | |
| 分子式 : | C22H19N3O5 | |
| 纯度 : | 99%+ | |
| 分子量 : | 405.4 | |
| MDL号 : | MFCD22666402 | |
| 存储条件： |
Pure form Sealed in dry, 2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Breast cancer resistance protein (BCRP) plays an important role in the development of multidrug resistance. KS176 is a potent and selective BCRP inhibitor with IC50 values of 1.39±0.26 and 0.59±0.24μM in Hoechst 33342 assay and Pheophorbide A assay, respectively. It shows no activity against P-glycoprotein or multidrug resistance-associated protein 1. The inhibitory potency of KS176 against BCRP was ~50-fold more potent than novobiocin and was only slightly less than that of Ko143. KS176 did not decrease cell viability in A2780 and MCF-7 cells at concentrations up to 10μM.[2] | ||
| 作用机制 | KS176 is an inhibitor of BCRP. It undergoes noncompetitive interaction with pheophorbide A.[2] | ||
| 实验方案 | |||
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| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.47mL 0.49mL 0.25mL |
12.33mL 2.47mL 1.23mL |
24.67mL 4.93mL 2.47mL |
| 参考文献 |
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