CD 437
产品说明书
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同义名 : | AHPN |
| CAS号 : | 125316-60-1 | |
| 货号 : | A570556 | |
| 分子式 : | C27H26O3 | |
| 纯度 : | 99%+ | |
| 分子量 : | 398.49 | |
| MDL号 : | MFCD03106506 | |
| 存储条件： |
Pure form Sealed in dry, store in freezer, under -20°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | CD437, a selective agonist for RARγ, shows its growth-inhibitory effects on lung cancer cell lines within 2 days when treated with 10 μM. Dose-response studies reveal that CD437 decreases the viability of H460, SK-MES-1, A549, and H292 cells, with IC50 values around 0.5, 0.4, 3, and 0.85 μM, respectively[1]. A 72-hour treatment with CD437 leads to a pronounced dose-dependent suppression of growth in all tested melanoma cell lines. With a 5 μM concentration of CD437, viability is reduced to approximately 5 to 25% after three days. The IC50 values for CD437, indicating 50% growth inhibition, vary from 10 μM in MeWo cells to 0.1 μM in SK-Mel-23 cells, the latter being the most sensitive[2]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.51mL 0.50mL 0.25mL |
12.55mL 2.51mL 1.25mL |
25.09mL 5.02mL 2.51mL |
