CD 437

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Chemical Structure| 125316-60-1 同义名 : AHPN
CAS号 : 125316-60-1
货号 : A570556
分子式 : C27H26O3
纯度 : 99%+
分子量 : 398.49
MDL号 : MFCD03106506
存储条件:

Pure form Sealed in dry, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月

溶解度 : -
动物实验配方:
生物活性
描述 CD437, a selective agonist for RARγ, shows its growth-inhibitory effects on lung cancer cell lines within 2 days when treated with 10 μM. Dose-response studies reveal that CD437 decreases the viability of H460, SK-MES-1, A549, and H292 cells, with IC50 values around 0.5, 0.4, 3, and 0.85 μM, respectively[1]. A 72-hour treatment with CD437 leads to a pronounced dose-dependent suppression of growth in all tested melanoma cell lines. With a 5 μM concentration of CD437, viability is reduced to approximately 5 to 25% after three days. The IC50 values for CD437, indicating 50% growth inhibition, vary from 10 μM in MeWo cells to 0.1 μM in SK-Mel-23 cells, the latter being the most sensitive[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.51mL

0.50mL

0.25mL

12.55mL

2.51mL

1.25mL

25.09mL

5.02mL

2.51mL