7-Chlorokynurenic Acid
产品说明书
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同义名 : | - |
| CAS号 : | 18000-24-3 | |
| 货号 : | A569101 | |
| 分子式 : | C10H6ClNO3 | |
| 纯度 : | 98% | |
| 分子量 : | 223.61 | |
| MDL号 : | MFCD00674924 | |
| 存储条件： |
Pure form Sealed in dry,2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | 7-Chlorokynurenic acid (7-CKA) is a potent and selective antagonist of the glycine B coagonist site of the N-methyl-D-aspartate (NMDA) receptor, with an IC50 of 0.56 μM. It is also a strong inhibitor of glutamate reuptake into synaptic vesicles, with a Ki of 0.59 μM. Additionally, 7-CKA has demonstrated powerful antinociceptive effects following neuraxial administration[1][2]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
4.47mL 0.89mL 0.45mL |
22.36mL 4.47mL 2.24mL |
44.72mL 8.94mL 4.47mL |
