Juglone

产品说明书

Print
Chemical Structure| 481-39-0 同义名 : 5-羟基对萘醌;胡桃酮;5-羟基-1,4-萘二酮 ;5-Hydroxy-1,4-naphthalenedione; 5-Hydroxy-1,4-naphthoquinone; Regianin; Akhnot; NSC 622948; NSC 153189; NSC 34266
CAS号 : 481-39-0
货号 : A565415
分子式 : C10H6O3
纯度 : 97%
分子量 : 174.15
MDL号 : MFCD00001684
存储条件:

Pure form Keep in dark place,Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月

溶解度 : -
动物实验配方:
生物活性
描述 Juglone, a natural product isolated and purified from the barks of Juglans regia L., significantly inhibits the proliferation and induce the apoptosis of SiHa cells and Caski cells, stimulates suicidal erythrocyte death or eryptosis at least in part by upregulation of ceramide abundance, energy depletion and activation of PKC, and prevents high-fat diet-induced liver injury and nerve inflammation in mice through inhibition of inflammatory cytokine secretion, NF-kappa B activation and endotoxin production.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

5.74mL

1.15mL

0.57mL

28.71mL

5.74mL

2.87mL

57.42mL

11.48mL

5.74mL

参考文献

[1]Peng X, Nie Y, et al. Juglone prevents metabolic endotoxemia-induced hepatitis and neuroinflammation via suppressing TLR4/NF-κB signaling pathway in high-fat diet rats. Biochem Biophys Res Commun. 2015 Jul 3;462(3):245-50.

[2]Calabro S, Alzoubi K, et al. Enhanced eryptosis following juglone exposure. Basic Clin Pharmacol Toxicol. 2015 Jun;116(6):460-7.