Ilginatinib HCl

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Chemical Structure| 1239358-85-0 同义名 : NS-018 hydrochloride; Ilginatinib hydrochloride
CAS号 : 1239358-85-0
货号 : A563170
分子式 : C21H21ClFN7
纯度 : 98+%
分子量 : 425.89
MDL号 : MFCD29472295
存储条件:

Pure form Inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月

溶解度 : -
动物实验配方:
生物活性
描述 NS-018 hydrochloride is a highly selective JAK2 inhibitor.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.35mL

0.47mL

0.23mL

11.74mL

2.35mL

1.17mL

23.48mL

4.70mL

2.35mL

参考文献

[1]Nakaya Y, Shide K, et al. Effect of NS-018, a selective JAK2V617F inhibitor, in a murine model of myelofibrosis. Blood Cancer J. 2014 Jan 10;4:e174.

[2]Kuroda J, Kodama A, et al. NS-018, a selective JAK2 inhibitor, preferentially inhibits CFU-GM colony formation by bone marrow mononuclear cells from high-risk myelodysplastic syndrome patients. Leuk Res. 2014 May;38(5):619-24.