Pterosin B
产品说明书
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同义名 : | - |
| CAS号 : | 34175-96-7 | |
| 货号 : | A559075 | |
| 分子式 : | C14H18O2 | |
| 纯度 : | 98+% | |
| 分子量 : | 218.29 | |
| MDL号 : | MFCD01719784 | |
| 存储条件： |
Pure form In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Pterosin B is a natural product isolated and purified from the aerial parts of Pteris semipinnata, is a salt-inducible kinase 3 (Sik3) pathway inhibitor, preventing chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3. Pterosin B has multiple targets in gluconeogenic programs, including coenzyme Q in RORα-SRC2 signaling, and shows cytotoxicity against HL 60 cells (human leukemia) with the IC(50) value of 8.7 mg/mL. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
4.58mL 0.92mL 0.46mL |
22.91mL 4.58mL 2.29mL |
45.81mL 9.16mL 4.58mL |
| 参考文献 |
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