Helicid
产品说明书
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同义名 : | Helicide; Helicidum; 4-formylphenyl-O-β-d-allopyranoside; 4-Formylphenyl-β-D-allopyranoside |
| CAS号 : | 80154-34-3 | |
| 货号 : | A556507 | |
| 分子式 : | C13H16O7 | |
| 纯度 : | 97% | |
| 分子量 : | 284.26 | |
| MDL号 : | MFCD00210992 | |
| 存储条件： |
Pure form Inert atmosphere, 2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
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| 描述 | Helicid (Helicide) is a major constituent of Helicia nilgirica Bedd. Helicid has been used to treat psychoneurosis for its sedative-hypnotic and analgesic properties. Helicid significantly regulated levels of corticosterone (CORT), inflammatory cytokines and 5-hydroxytryptamine (5-HT). Helicid also reversed CUMS-induced decreases of 5-HT1A receptor expression and promoted brain derived neurotrophic factor (BDNF) expression in the hippocampus. The significant reversal of depressive-like behaviors by helicid is similar to that achieved by fluoxetine[2]. Helicid is an effective agent for both neuropathic pain and sleep disturbances in partial sciatic nerve ligated mice. Immunohistochemical study showed that helicid (400 mg/kg ) administration could reverse the increase of c-Fos expression in the neurons of the rostral anterior cingulate cortex and tuberomammillary nucleus, and the decrease of c-Fos expression in the ventrolateral preoptic area caused by partial sciatic nerve ligation[3]. Helicid could improve depressive behaviors, learning and cognitive deficits and increase hippocampal neurogenesis, which may be mediated by the regulation of SERTs(serotonin transporters), activation of the cAMP/PKA/CREB signaling pathway and upregulation of p-CREB (cAMP response element-binding) levels in hippocampal[4]. | ||
| 实验方案 | |||
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| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
3.52mL 0.70mL 0.35mL |
17.59mL 3.52mL 1.76mL |
35.18mL 7.04mL 3.52mL |
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