DiethylcarbamazineCitrate
产品说明书
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同义名 : | 枸橼酸乙胺嗪 ;Diethylcarbamazine(citrate) |
| CAS号 : | 1642-54-2 | |
| 货号 : | A553770 | |
| 分子式 : | C16H29N3O8 | |
| 纯度 : | 98% | |
| 分子量 : | 391.42 | |
| MDL号 : | MFCD00039124 | |
| 存储条件： |
Pure form Inert atmosphere, room temperature In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Diethylcarbamazine citrate is an inhibitor of arachidonic acid metabolism in filarial microfilaria; is highly specific for several parasites and does not contain any toxic metallic elements[2]. Diethylcarbamazine citrate (DEC) is also anti-inflammatory drug. The only effective anti-inflammatory dose was 50mg/kg to reduce the high levels of glucose, insulin and triglycerides in serum. DEC was not anti-obesity drug because the weights of body, liver and adipose tissues were not changed. In addition, the activity of COX (cyclooxygenase) in DEC treatment decreased significantly, while NF-κBp65 localization in nuclear extracts was obviously inhibited in 50mg/kg treated group[3]. Within 10 s of an intravenous injection of DECC(diethylcarbamazine citrate) (2.5 to 10 mg/kg) there was hypotension, bradycardia and there were reductions in left ventricular and carotid artery dP/dt max. DECC (5 or 10 mg/kg) significantly inhibited prostaglandin F2alpha-induced increases in peak inspiratory intra-tracheal pressure without modifying its pulmonary hypertensive effect[4]. The effect of S. equina ES (excretory-secretory) as antioxidant against rat HCC (hepatocellular carcinoma ), while DEC could modulate such effect when combined with it[5]. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT01905423 | - | Completed | - | Indonesia ... 展开 >> University of Indonesia, Department of Parasitology Jakarta, Java, Indonesia, 10430 收起 << | |
| NCT01905423 | - | Completed | - | - | |
| NCT03676140 | Trachoma Yaws... 展开 >> Lymphatic Filariases Scabies Strongyloidiasis 收起 << | Phase 3 | Not yet recruiting | January 2019 | - |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.55mL 0.51mL 0.26mL |
12.77mL 2.55mL 1.28mL |
25.55mL 5.11mL 2.55mL |
| 参考文献 |
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