SRT 1460
产品说明书
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同义名 : | - |
| CAS号 : | 925432-73-1 | |
| 货号 : | A548750 | |
| 分子式 : | C26H29N5O4S | |
| 纯度 : | 95+% | |
| 分子量 : | 507.6 | |
| MDL号 : | MFCD19053214 | |
| 存储条件： |
Pure form Inert atmosphere, 2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Sirtuin-1 (SIRT1), a NAD+-dependent deacetylase, is a principal modulator of pathways downstream of calorie restriction that produce beneficial effects on glucose homeostasis and insulin sensitivity. SRT1460 is a potent SIRT1 activator with an EC1.5 (concentration required to increase enzyme activity by 50%) value of 2.9 μM, shows good selectivity for activation of SIRT1 versus SIRT2 and SIRT3 (EC1.5>300 μM), and is more potent than Resveratrol and the closest sirtuin homologues[1]. Treatment with different concentrations of SRT1460 inhibited cell viability in a dose-dependent manner, with all pancreatic cancer cells being more sensitive than the control HPDE cell. SRT1460 was also shown to inhibited cell growth by the Trypan blue exclusion and in the anchorage-independent cell growth assays in Patu8988t[2]. | ||
| 作用机制 | SRT1460 binds to the SIRT1 enzyme-peptide substrate complex at an allosteric site amino-terminal to the catalytic domain[1]. | ||
| 实验方案 | |||
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| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
1.97mL 0.39mL 0.20mL |
9.85mL 1.97mL 0.99mL |
19.70mL 3.94mL 1.97mL |
| 参考文献 |
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