GK921
产品说明书
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同义名 : | - |
| CAS号 : | 1025015-40-0 | |
| 货号 : | A546387 | |
| 分子式 : | C21H20N4O | |
| 纯度 : | 99%+ | |
| 分子量 : | 344.41 | |
| MDL号 : | MFCD28167818 | |
| 存储条件： |
Pure form Sealed in dry, 2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | GK921 inhibits TGase 2-induced polymerization of I-κBα and p53 in a dose-dependent manner. Its cytotoxicity ranges from GI50 of 10-10 to 10-4 M, with an average GI50 of 9.05×10-7 M. GK921 restores p53 levels, leading to apoptosis induction; a concentration-dependent rise in cleaved poly(ADP-ribose) polymerase (c-PARP) and p53 levels is noted [1]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.90mL 0.58mL 0.29mL |
14.52mL 2.90mL 1.45mL |
29.04mL 5.81mL 2.90mL |
| 参考文献 |
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