(-)-Dizocilpine maleate

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Chemical Structure| 121917-57-5 同义名 : (-)-MK-801 maleate; (-)-MK 801 (Maleate); (-)-MK 801 hydrogen maleate; C13737
CAS号 : 121917-57-5
货号 : A542047
分子式 : C20H19NO4
纯度 : 98%
分子量 : 337.37
MDL号 : MFCD00082466
存储条件：

Pure form Inert atmosphere, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
靶点

  • NMDA receptor

    NMDA receptor, Ki:30.5 nM

  • NMDA receptor

    NMDA receptor, Ki:30.5 nM
描述 (-)-MK 801 maleate is the enantiomer of (+)-MK-801, which is a highly potent and selective non-competitive NMDA glutamate receptor antagonist .
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.96mL

0.59mL

0.30mL

14.82mL

2.96mL

1.48mL

29.64mL

5.93mL

2.96mL
参考文献

[1]Wise-Faberowski L, Pearlstein RD, et al. NMDA-induced apoptosis in mixed neuronal/glial cortical cell cultures: the effects of isoflurane and dizocilpine. J Neurosurg Anesthesiol. 2006 Oct;18(4):240-6.

[2]Wong EH, Kemp JA, et al. The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist. Proc Natl Acad Sci U S A. 1986 Sep;83(18):7104-8.