Flumatinib

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Chemical Structure| 895519-90-1 同义名 : HHGV678
CAS号 : 895519-90-1
货号 : A535256
分子式 : C29H29F3N8O
纯度 : 99%+
分子量 : 562.59
MDL号 : MFCD18633213
存储条件：

Pure form Keep in dark place, sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 Flumatinib (HHGV678) is an oral, selective Bcr-Abl inhibitor. It effectively targets c-Abl, PDGFRβ, and c-Kit with IC50 values of 1.2 nM, 307.6 nM, and 665.5 nM, respectively [1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.78mL

0.36mL

0.18mL

8.89mL

1.78mL

0.89mL

17.77mL

3.55mL

1.78mL
参考文献

[1]Luo H, et al. HH-GV-678, a novel selective inhibitor of Bcr-Abl, outperforms imatinib and effectively overrides imatinib resistance. Leukemia. 2010 Oct;24(10):1807-9.

[2]Zhao J, et al. Flumatinib, a selective inhibitor of BCR-ABL/PDGFR/KIT, effectively overcomes drug resistance of certain KIT mutants. Cancer Sci. 2013 Nov 10.