Turanose

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Chemical Structure| 547-25-1 同义名 : D(+)-松二糖 ;D-(+)-Turanose
CAS号 : 547-25-1
货号 : A526766
分子式 : C12H22O11
纯度 : 98%
分子量 : 342.3
MDL号 : MFCD00006606
存储条件:

Pure form Sealed in dry, room temperature

In solvent -20°C:3-6个月-80°C:12个月

溶解度 : -
动物实验配方:
生物活性
描述 Turanose (3-O-α-D-glucosyl-D-fructose), an isomer of sucrose, naturally exists in honey. Turanose has anti-inflammatory and regulates adipogenesis effect[1]. Turanose, a potential novel sweetener in food industry, can be synthesized by Neisseria polysaccharea amylosucrase (NpAS)[2]. In addition, no changes in body weight or food consumption were observed and the median lethal dose (LD50) for oral intake of turanose was determined to be greater than 10 g/kg b.w[3]. In physiological functionality test, lipid accumulation in 3T3-L1 preadipocytes in the presence of high amounts of pure glucose was attenuated by turanose substitution in a dose-dependent manner. Turanose treatments at concentrations representing 50%, 75%, and 100% of total glucose concentration in cell media significantly reduced lipid accumulation by 18%, 35%, and 72%, respectively, as compared to controls[4].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.92mL

0.58mL

0.29mL

14.61mL

2.92mL

1.46mL

29.21mL

5.84mL

2.92mL

参考文献

[1]Chung JY, Kim YS, Kim Y, Yoo SH. Regulation of Inflammation by Sucrose Isomer, Turanose, in Raw 264.7 Cells. J Cancer Prev. 2017 Sep;22(3):195-201

[2]Su L, Zhao Y, Wu D, Wu J. Heterogeneous expression, molecular modification of amylosucrase from Neisseria polysaccharea, and its application in the preparation of turanose. Food Chem. 2020 Jun 1;314:126212

[3]Chung JY, Lee J, Lee D, Kim E, Shin JH, Seok PR, Yoo SH, Kim Y. Acute and 13-week subchronic toxicological evaluations of turanose in mice. Nutr Res Pract. 2017 Dec;11(6):452-460

[4]Park MO, Lee BH, Lim E, Lim JY, Kim Y, Park CS, Lee HG, Kang HK, Yoo SH. Enzymatic Process for High-Yield Turanose Production and Its Potential Property as an Adipogenesis Regulator. J Agric Food Chem. 2016 Jun 15;64(23):4758-64