同义名 :	ABR 25757; ABR-215757
	CAS号 :	248282-01-1
	货号 :	A525721
	分子式 :	C21H22N2O3
	纯度 :	99%+
	分子量 :	350.41
	MDL号 :	MFCD18633277
	存储条件：	Pure form Sealed in dry,2-8°C In solvent -20°C:3-6个月-80°C:12个月
	溶解度 :	-
	动物实验配方：

生物活性
描述	Paquinimod, also known as ABR 215757, is a targeted and orally administered inhibitor of S100A8/S100A9. It effectively alleviates pneumonia and significantly lowers viral counts in mice infected with SARS-CoV-2[1][2][3].
作用机制	Paquinimod specifically inhibit the interaction of S100A9 via directly binding to S100A9.

临床研究
NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT01487551	Systemic Sclerosis	Phase 2	Completed	-	Germany ... 展开 >> Berlin, Germany Cologne, Germany Erlangen, Germany Sweden Gothenburg, Sweden Lund, Sweden Switzerland Zürich, Switzerland 收起 <<
NCT00997100	Systemic Lupus Erythematosus	Phase 2	Completed	-	Denmark ... 展开 >> Soren Jacobsen Copenhagen, Denmark, 2100 Sweden Dept of Rheumatology, University Hospital in Lund Lund, Sweden, 220 07 Iva Gunnarsson M.D. Stockholm, Sweden, 171 76 Lars Rönnblom M.D. Uppsala, Sweden, 751 85 收起 <<

实验方案
	1mg	5mg	10mg
1 mM 5 mM 10 mM	2.85mL 0.57mL 0.29mL	14.27mL 2.85mL 1.43mL	28.54mL 5.71mL 2.85mL