LB-100

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Chemical Structure| 1632032-53-1 同义名 : -
CAS号 : 1632032-53-1
货号 : A524930
分子式 : C13H20N2O4
纯度 : 98%+
分子量 : 268.31
MDL号 : MFCD28167839
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 LB-100, acting as an inhibitor of protein phosphatase 2A (PP2A), shows IC50 values of 0.85 μM and 3.87 μM in BxPc-3 and Panc-1 cells, respectively, indicating its potent inhibitory action[1].[2].[3].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.73mL

0.75mL

0.37mL

18.64mL

3.73mL

1.86mL

37.27mL

7.45mL

3.73mL
参考文献

[1]Bai X, et al. Inhibition of protein phosphatase 2A sensitizes pancreatic cancer to chemotherapy by increasing drug perfusion via HIF-1α-VEGF mediated angiogenesis. Cancer Lett. 2014 Oct 7. pii: S0304-3835(14)00589-8.

[2]Bai XL, et al. Inhibition of protein phosphatase 2A enhances cytotoxicity and accessibility of chemotherapeutic drugs to hepatocellular carcinomas. Mol Cancer Ther. 2014 Aug;13(8):2062-72.

[3]Fu QH, et al. LB-100 sensitizes hepatocellular carcinoma cells to the effects of sorafenib during hypoxia by activation of Smad3 phosphorylation. Tumour Biol. 2016 Jun;37(6):7277-8