TCN 201

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Chemical Structure| 852918-02-6 同义名 : -
CAS号 : 852918-02-6
货号 : A524469
分子式 : C21H17ClFN3O4S
纯度 : 99%+
分子量 : 461.89
MDL号 : MFCD06683895
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 TCN 201 is a potent, selective, and non-competitive antagonist of the GluN1/GluN2A NMDA receptor, exhibiting a pIC50 value of 6.8. It shows selectivity for the GluN1/GluN2A NMDA receptor over the GluN1/GluN2B NMDA receptor (pIC50<4.3) [1][2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.17mL

0.43mL

0.22mL

10.83mL

2.17mL

1.08mL

21.65mL

4.33mL

2.17mL
参考文献

[1]Bettini E, et, al. Identification and characterization of novel NMDA receptor antagonists selective for NR2A- over NR2B-containing receptors. J Pharmacol Exp Ther. 2010 Dec; 335(3): 636-44.

[2]Edman S, et, al. TCN 201 selectively blocks GluN2A-containing NMDARs in a GluN1 co-agonist dependent but non-competitive manner. Neuropharmacology. 2012 Sep; 63(3): 441-9.

[3]Bu F, et, al. NR2A contributes to genesis and propagation of cortical spreading depression in rats. Sci Rep. 2016 Mar 22;6:23576.

[4]Shatillo A, et, al. Involvement of NMDA receptor subtypes in cortical spreading depression in rats assessed by fMRI. Neuropharmacology. 2015 Jun; 93:164-70.