Metamizole Sodium Salt
产品说明书
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同义名 : | 安乃近 ;Metamizole sodium; Dipyrone; Metamizole(sodium) |
| CAS号 : | 68-89-3 | |
| 货号 : | A524152 | |
| 分子式 : | C13H16N3NaO4S | |
| 纯度 : | 99+% | |
| 分子量 : | 333.34 | |
| MDL号 : | MFCD00020783 | |
| 存储条件： |
Pure form Inert atmosphere, room temperature In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
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| 描述 | Dipyrone (Metamizole) is a nonsteroidal compound with strong analgesic as well as antipyretic and spasmolytic properties[1]. Dipyrone has analgesic, spasmolytic, and antipyretic effects and is used to treat pain. The analgesic efficacy of intravenous dipyrone appears similar to that of intravenous paracetamol[2]. Dipyrone can be recommended for the treatment of cancer pain as an alternative to other non-opioids either alone or in combination with opioids[3]. Dipyrone can block both PG-dependent and PG-independent pathways of fever induced by LPS, which suggests that this drug has a profile of antipyretic action distinctly different from that of NSAIDs. The mechanism responsible for the spasmolytic effect of metamizole is associated with the inhibited release of intracellular Ca2+ as a result of the reduced synthesis of inositol phosphate[4]. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT01850446 | Influenza | Phase 4 | Recruiting | December 2018 | Russian Federation ... 展开 >> The Non-State Health Care Institution "Road Hospital of the Open Joint Stock Company" Russian Railways" Recruiting Chelyabinsk, Russian Federation, 454091 Contact: Yulia Shapovalova, MD PhD Principal Investigator: Yulia Shapovalova, MD PhD The State Budgetary Educational Institution of Higher Professional Education " Kazan State University of Medicine" Ministry of Health of the Russian Federation Recruiting Kazan, Russian Federation, 420012 Contact: Rustem Hamitov, MD, PhD, ScD, professor Principal Investigator: Rustem Hamitov, MD, PhD, ScD, professor Pirogov Russian National Research Medical University Not yet recruiting Moscow, Russian Federation, 117997 Contact: Boris Bart, MD, PhD, ScD, professor Principal Investigator: Boris Bart, MD, PhD, ScD, professor Pirogov Russian National Research Medical University Recruiting Moscow, Russian Federation, 117997 Contact: Marina Mikhaylusova, MD, PhD Principal Investigator: Marina Mikhaylusova, MD, PhD Limited Liability Company "Scientific Research Centre Eco-safety" Recruiting Saint Petersburg, Russian Federation, 196143 Contact: Rodion Oseshnyuk, MD, PhD Principal Investigator: Rodion Oseshnyuk, MD, PhD St. Petersburg State Budgetary Healthcare Institution "City polyclinic №106" Not yet recruiting Saint Petersburg, Russian Federation, 198328 Contact: Daniel Chizhov, MD Principal Investigator: Daniel Chizhov, MD Non-state health facility "Road Hospital Open Joint Stock Company" Russian Railways" Not yet recruiting Sankt Petersburg, Russian Federation, 195271 Contact: Konstantin Penkov, MD Principal Investigator: Konstantin Penkov, MD Regional State Budgetary Healthcare Institution "Clinical Hospital №1" Recruiting Smolensk, Russian Federation, 214006 Contact: Vladimir Rafalsky, PhD, professor Principal Investigator: Vladimir Rafalsky, PhD, professor State Federal-Funded Educational Institution of Higher Training Smolensk State Medical University of the Ministry of Health of the Russian Federation Not yet recruiting Smolensk, Russian Federation, 214019 Contact: Oleg Kozyrev, Prof Principal Investigator: Oleg Kozyrev, Prof St. Petersburg State Budgetary Health Care Institution " Nevsky Region Сity Polyclinic №25" Withdrawn St. Petersburg, Russian Federation, 193312 Federal State Budgetary Military Educational Institution of Higher Professional Education "Military-Medicine Academy named after S. M. Kirov" of Ministry of Defence of Russian Federation Recruiting St. Petersburg, Russian Federation, 194044 Contact: Konstantin Zhdanov, MD, PhD, ScD, Professor Principal Investigator: Konstantin Zhdanov, MD, PhD, ScD, Professor St. Petersburg State Budgetary Health Care Institution " City policlinic No. 117" Completed St. Petersburg, Russian Federation, 194358 收起 << |
| NCT01389089 | Edema | Phase 4 | Completed | - | Switzerland ... 展开 >> Luzerner Kantonsspital, Unfallchirurgie Luzern, Switzerland, 6000 16 收起 << |
| NCT01847898 | Vertebral Body Fractures | Phase 4 | Completed | - | Austria ... 展开 >> Universitätsklinik für Unfallchirurgie Graz, Austria AKH Wien, Austria Germany Universitätsklinikum Schleswig-Holstein Kiel, Germany Universitätsklinikum Münster, Germany Universitätsklinik und Poliklinik für Chirurgie Rostock, Germany 收起 << |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
3.00mL 0.60mL 0.30mL |
15.00mL 3.00mL 1.50mL |
30.00mL 6.00mL 3.00mL |
| 参考文献 |
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