同义名 :	SCE-2787 hydrochloride; Cefozopran hydrochloride
	CAS号 :	113981-44-5
	货号 :	A522832
	分子式 :	C19H18ClN9O5S2
	纯度 :	99%+
	分子量 :	551.99
	MDL号 :	MFCD00944908
	存储条件：	Pure form Inert atmosphere, 2-8°C In solvent -20°C:3-6个月-80°C:12个月
	溶解度 :	-
	动物实验配方：

生物活性

描述

Cefozopran (HCl) is a parenteral cephalosporin with a broad spectrum of activity against Gram-positive and Gram-negative bacteria[3]. Cefozopran hydrochloride performs a linear kinetics in healthy volunteers. The main pharmacokinetic parameters have no significant gender differences, and there is no drug accumulated with multiple doses of injection[4]. Moreover, 20- or 40-mg/kg four times a day (0.5-h infusions), provided sufficient bactericidal effects on common bacterial populations (Escherichia coli, Streptococcus pneumoniae, Haemophilus influenzae, and Pseudomonas aeruginosa) in most typical patients[5]. Cefozopran is an effective and safe antibiotic for the treatment of febrile neutropenia in patients with hematological malignancies[6].

实验方案
	1mg	5mg	10mg
1 mM 5 mM 10 mM	1.81mL 0.36mL 0.18mL	9.06mL 1.81mL 0.91mL	18.12mL 3.62mL 1.81mL

参考文献

[1]Zalewski P, Garbacki P, et al. DEVELOPMENT AND VALIDATION OF THE STABILITY-INDICATING LC-UV METHOD FOR DETERMINATION OF CEFOZOPRAN HYDROCHLORIDE. Acta Pol Pharm. 2015 May-Jun;72(3):423-7. [2]Zalewski P, Skibiński R, et al. Stability of cefozopran hydrochloride in aqueous solutions. Drug Dev Ind Pharm. 2016;42(4):572-7. [3]Wu GL, Shentu JZ, Zhou HL, et al. Pharmacokinetics of cefozopran by single and multiple intravenous infusions in healthy Chinese volunteers. Drugs R D. 2015;15(1):63‐70 [4]Guo WW, Shen Q, Qin YP, et al. Sichuan Da Xue Xue Bao Yi Xue Ban. 2012;43(5):711‐714 [5]Ikawa K, Kozumi T, Ikeda K, Morikawa N, Kobayashi R. Population pharmacokinetic modeling and pharmacodynamic assessment of cefozopran in pediatric patients. Jpn J Antibiot. 2009;62(5):435‐444 [6]Saito T, Hara M, Shinagawa K, et al. Gan To Kagaku Ryoho. 2004;31(1):61‐65