ML216

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Chemical Structure| 1430213-30-1 同义名 : CID-49852229
CAS号 : 1430213-30-1
货号 : A522753
分子式 : C15H9F4N5OS
纯度 : 99%+
分子量 : 383.32
MDL号 : MFCD24849400
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
靶点

  • helicase

    BLMfull-length, IC50:2.98 μM

    BLM636-1298, IC50:0.97 μM

  • helicase

    BLMfull-length, IC50:2.98 μM

    BLM636-1298, IC50:0.97 μM
描述 ML216 (CID-49852229) acts as a powerful, selective, and cell-penetrable blocker of BLM helicase's DNA unwinding function, exhibiting IC50 values of 2.98 μM for BLM full-length and 0.97 μM for BLM636-1298. Additionally, ML216 suppresses BLM's ssDNA-dependent ATPase activity with a Ki of 1.76 µM, displaying antitumor activity[1][2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.61mL

0.52mL

0.26mL

13.04mL

2.61mL

1.30mL

26.09mL

5.22mL

2.61mL
参考文献

[1]Nguyen GH, et al. A small molecule inhibitor of the BLM helicase modulates chromosome stability in human cells. Chem Biol. 2013 Jan 24;20(1):55-62.

[2]Banerjee T, et al. A new development in DNA repair modulation: discovery of a BLM helicase inhibitor. Cell Cycle. 2013 Mar 1;12(5):713-4.