Dihydrocoumarin
产品说明书
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同义名 : | 苯并二氢吡喃-2-酮;1,2-苯并二氢吡喃酮;氢化肉桂酸内酯;二氢色满酮;二羟基香豆素;苯并二氢吡喃酮;二氢香豆酯;二氢香兰素 ;Hydrocoumarin; Chroman-2-one; DHC |
| CAS号 : | 119-84-6 | |
| 货号 : | A521655 | |
| 分子式 : | C9H8O2 | |
| 纯度 : | 97% | |
| 分子量 : | 148.16 | |
| MDL号 : | MFCD00006881 | |
| 存储条件： |
Pure form Keep in dark place, inert atmosphere, room temperature In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
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| 描述 | Dihydrocoumarin (DHC) is an inhibitor of the Sirtuin family of NAD+-dependent deacetylases[3]. Dihydrocoumarin also inhibits human SIRT1 and SIRT2 with IC50s of 208 μM and 295 μM, respectively. The microtubule SIRT2 deacetylase is also inhibited with a similar dose dependency (IC50 of 295 μM). Dihydrocoumarin (1-5 mM) increases cytotoxicity in the TK6 cell line in a dose-dependent manner following a 24-h exposure. Dihydrocoumarin (1-5 mM) increases apoptosis in a dose-dependent manner in the TK6 cell line at the 6-h time point. Dihydrocoumarin (1-5 mM) increases p53 lysine 373 and 382 acetylation in a dose-dependent manner in the TK6 cell line following a 24-h exposure period[4]. Dihydrocoumarin disrupted heterochromatic silencing and inhibited yeast Sir2p as well as human SIRT1 deacetylase activity. DHC exposure in the human TK6 lymphoblastoid cell line also caused concentration-dependent increases in p53 acetylation and cytotoxicity[4]. | ||
| 实验方案 | |||
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| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
6.75mL 1.35mL 0.67mL |
33.75mL 6.75mL 3.37mL |
67.49mL 13.50mL 6.75mL |
| 参考文献 |
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