TBPB

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Chemical Structure| 634616-95-8 同义名 : -
CAS号 : 634616-95-8
货号 : A515677
分子式 : C25H32N4O
纯度 : 98%
分子量 : 404.55
MDL号 : MFCD22666590
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 TBPB is an allosteric M1 mAChR agonist (EC50=289 nM) that regulates amyloid processing and produces antipsychotic-like activity in rats.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.47mL

0.49mL

0.25mL

12.36mL

2.47mL

1.24mL

24.72mL

4.94mL

2.47mL
参考文献

[1]Jones CK, Brady AE, et al. Novel selective allosteric activator of the M1 muscarinic acetylcholine receptor regulates amyloid processing and produces antipsychotic-like activity in rats. J Neurosci. 2008 Oct 8;28(41):10422-33.

[2]Miller NR, Daniels RN, et al. Synthesis and SAR of analogs of the M1 allosteric agonist TBPB. Part II: Amides, sulfonamides and ureas--the effect of capping the distal basic piperidine nitrogen. Bioorg Med Chem Lett. 2008 Oct 15;18(20):5443-7.