Acamprosate calcium
产品说明书
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同义名 : | Calcium N-acetylhomotaurinate; Acamprosate(calcium salt); N-acetyl Homotaurine; N-acetyl Homotaurinate; Acamprosate(calcium) |
| CAS号 : | 77337-73-6 | |
| 货号 : | A512508 | |
| 分子式 : | C10H20CaN2O8S2 | |
| 纯度 : | 97% | |
| 分子量 : | 400.48 | |
| MDL号 : | MFCD00886588 | |
| 存储条件： |
Pure form Sealed in dry,2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Acamprosate calcium(Campral EC) is a GABA receptor agonist and modulator of glutamatergic systems; reduces alcohol consumption in animal models of alcohol addiction. Acamprosate has low bioavailability, but also has an excellent tolerability and safety profile. Acamprosate is unique in that it is not metabolized by the liver and is also not impacted by alcohol use, so can be administered to patients with hepatitis or liver disease (a common comorbid condition among individuals with alcohol dependence) and to patients who continue drinking alcohol[3]. Acamprosate calcium may be effective augmentation therapy in patients with treatment-resistant anxiety[4]. Acamprosate and naltrexone are established strategies for pharmacologic relapse prevention in patients with alcohol dependence. The combined treatment with both agents should be considered in patients who did not achieve abstinence under monotherapy unless contraindications are present[5]. Moreover, acamprosate (200 mg/kg) may induce antidepressant-like effect and that NMDA and mGlu5 receptors are crucial targets of acamprosate in this action[6]. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT02374567 | Dementia Depr... 展开 >>ession Schizophrenia Psychosomatic Disorders Anxiety Disorders 收起 << | Phase 3 | Terminated | - | Germany ... 展开 >> Bezirkskrankenhaus Augsburg Augsburg, Germany Krankenhaus Hedwigshöhe Berlin, Germany Hannover Medical School Hannover, Germany, 30625 Asklepios Fachklinikum Lübben Lübben, Germany Asklepios Fachklinikum Teupitz Teupitz, Germany 收起 << |
| NCT01437046 | Alcohol Dependence ... 展开 >> Anxiety 收起 << | Phase 2 | Completed | - | United States, Rhode Island ... 展开 >> Brown University Center for Alcohol and Addiction Studies Providence, Rhode Island, United States, 02903 收起 << |
| NCT01343628 | Alcohol-induced Cue-craving ... 展开 >> Alcohol Sensitivity 收起 << | Phase 1 | Terminated(Terminated due to l... 展开 >>ack of funding) 收起 << | - | United States, Virginia ... 展开 >> Center for Addiction Research and Education Charlottesville/ Richmond, Virginia, United States, 22903 收起 << |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
2.50mL 0.50mL 0.25mL |
12.49mL 2.50mL 1.25mL |
24.97mL 4.99mL 2.50mL |
| 参考文献 |
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