NKY80
产品说明书
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同义名 : | Adenylyl Cyclase Type V Inhibitor |
| CAS号 : | 299442-43-6 | |
| 货号 : | A507715 | |
| 分子式 : | C12H11N3O2 | |
| 纯度 : | 95% | |
| 分子量 : | 229.23 | |
| MDL号 : | MFCD02026323 | |
| 存储条件： |
Pure form Keep in dark place, inert atmosphere, 2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
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| 描述 | NKY80 is a potent, selective, non-competitive inhibitor of adenylyl cyclase type V isoform, with IC50 values of 8.3 µM, 132 µM, and 1.7 mM for types V, III, and II, respectively. NKY80 is a non-nucleoside quinazoline ketone that modulates the adenylyl cyclase catalytic activity in cardiac and pulmonary tissues [1][2]. cyclase catalytic activity in cardiopulmonary tissues [1][2].NKY80 at a concentration of 20 μM blocks the elevation of LVP and ventricular cAMP levels[2] .NKY80 at a concentration of 20 μM for 2 hours completely blocked the increase in cAMP levels and renin release in isolated JG cells[3] . | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
4.36mL 0.87mL 0.44mL |
21.81mL 4.36mL 2.18mL |
43.62mL 8.72mL 4.36mL |
