同义名 :	Symmetric dimethylarginine; NG,NG'-Dimethyl-L-arginine
	CAS号 :	30344-00-4
	货号 :	A507261
	分子式 :	C8H18N4O2
	纯度 :	98%
	分子量 :	202.25
	MDL号 :	-
	存储条件：	Pure form Sealed in dry,2-8°C In solvent -20°C:3-6个月-80°C:12个月
	溶解度 :	-
	动物实验配方：

生物活性

描述

SDMA (Symmetric dimethylarginine) is an endogenous inhibitor of nitric oxide (NO) synthase activity. SDMA does not directly inhibit NOS but is a competitor of arginine transport. SDMA is primarily eliminated by renal excretion and is a promising endogenous marker of glomerular filtration rate. SDMA inhibited dose dependently the NO synthesis in intact endothelial cells, whereas it had no effect on protein expression of NOS[1]. SDMA is involved in the inflammatory process of chronic kidney disease, activating NF-κB and resulting in enhanced expression of IL-6 and TNF-α[2]. Chronic SDMA infusion leads to a significant increase of SDMA levels in mice, but the GFR (glomerular filtration rate) did not change at 4 weeks. No histological changes are observed, particularly no effect on fibrosis or endothelias nitric oxide synthase expression. There is neither an effect of SDMA on systolic blood pressure nor on ejection fraction[4]. SDMA is highly stable in serum and plasma, and the assay demonstrates excellent analytical performance. In unaffected dogs, SDMA remains unchanged whereas in affected dogs, SDMA increases during disease progression, correlating strongly with an increase in sCr and decrease in GFR[3].

实验方案
	1mg	5mg	10mg
1 mM 5 mM 10 mM	4.94mL 0.99mL 0.49mL	24.72mL 4.94mL 2.47mL	49.44mL 9.89mL 4.94mL

参考文献

[1]Bode-Böger SM, Scalera F, Kielstein JT, et al. Symmetrical dimethylarginine: a new combined parameter for renal function and extent of coronary artery disease. J Am Soc Nephrol. 2006;17(4):1128‐1134 [2]Schepers E, Barreto DV, Liabeuf S, et al. Symmetric dimethylarginine as a proinflammatory agent in chronic kidney disease [published correction appears in Clin J Am Soc Nephrol. 2012 May;7(5):874]. Clin J Am Soc Nephrol. 2011;6(10):2374‐2383 [3]Nabity MB, Lees GE, Boggess MM, et al. Symmetric Dimethylarginine Assay Validation, Stability, and Evaluation as a Marker for the Early Detection of Chronic Kidney Disease in Dogs. J Vet Intern Med. 2015;29(4):1036‐1044 [4]Veldink H, Faulhaber-Walter R, Park JK, et al. Effects of chronic SDMA infusion on glomerular filtration rate, blood pressure, myocardial function and renal histology in C57BL6/J mice. Nephrol Dial Transplant. 2013;28(6):1434‐1439