RO4987655

产品说明书

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Chemical Structure| 874101-00-5 同义名 : CH4987655
CAS号 : 874101-00-5
货号 : A499181
分子式 : C20H19F3IN3O5
纯度 : 97%
分子量 : 565.28
MDL号 : MFCD19443685
存储条件：

Pure form Keep in dark place, sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
生物活性
描述 RO4987655 is an orally active small molecule, targeting mitogen-activated protein kinase kinase 1 (MAP2K1/MEK1 IC50=5.2 nM), with potential antineoplastic activity.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.77mL

0.35mL

0.18mL

8.85mL

1.77mL

0.88mL

17.69mL

3.54mL

1.77mL
参考文献

[1]Leijen S, Middleton MR, et al. Phase I dose-escalation study of the safety, pharmacokinetics, and pharmacodynamics of the MEK inhibitor RO4987655(CH4987655) in patients with advanced solid tumors. Clin Cancer Res. 2012 Sep 1;18(17):4794-805.

[2]Lee L, Niu H, et al. The safety, tolerability, pharmacokinetics, and pharmacodynamics of single oral doses of CH4987655 in healthy volunteers: target suppression using a biomarker. Clin Cancer Res. 2009 Dec 1;15(23):7368-74.