NS11394

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Chemical Structure| 951650-22-9 同义名 : -
CAS号 : 951650-22-9
货号 : A498096
分子式 : C23H19N3O
纯度 : 98%
分子量 : 353.42
MDL号 : MFCD14635200
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 NS11394 is a potent and subtype-selective GABA (A) receptor-positive modulator, possessing a functional efficacy selectivity profile of alpha(5) > alpha(3) > alpha(2) > alpha(1) at GABA (A) alpha subunit-containing receptors.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.83mL

0.57mL

0.28mL

14.15mL

2.83mL

1.41mL

28.29mL

5.66mL

2.83mL
参考文献

[1]Munro G, Lopez-Garcia JA, et al. Comparison of the novel subtype-selective GABAA receptor-positive allosteric modulator NS11394 [3'-[5-(1-hydroxy-1-methyl-ethyl)-benzoimidazol-1-yl] -biphenyl-2-carbonitrile] with diazepam, zolpidem, bretazenil, and gaboxadol in rat models of inflammatory and neuropathic pain. J Pharmacol Exp Ther. 2008 Dec;327(3):969-81.

[2]Mirza NR, Larsen JS, et al. NS11394 [3'-[5-(1-hydroxy-1-methyl-ethyl)-benzoimidazol-1-yl] -biphenyl-2-carbonitrile] , a unique subtype-selective GABAA receptor positive allosteric modulator: in vitro actions, pharmacokinetic properties and in vivo anxiolytic efficacy. J Pharmacol Exp Ther. 2008 Dec;327(3):954-68.