Go6976
产品说明书
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同义名 : | PD406976 |
| CAS号 : | 136194-77-9 | |
| 货号 : | A494051 | |
| 分子式 : | C24H18N4O | |
| 纯度 : | 99%+ | |
| 分子量 : | 378.43 | |
| MDL号 : | MFCD00236434 | |
| 存储条件： |
Pure form Sealed in dry, 2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
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| 靶点 |
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| 描述 | Go6976, a staurosporine analog, is an effective PKC inhibitor with an IC50 value of 20 nM[1]. Go6976 has been shown to eliminate S and G2 phase arrests. Dose-response experiments indicate that 30 nM of Go6976 can lift the S-phase arrest in 6 hours and the G2 arrest, leading to fatal mitosis after 24 hours. Treating cells with 100 nM Go6976 effectively removes S and G2 phase arrests at 6 and 24 hours, respectively, with a potency just marginally less than that of bovine serum. Cell viability is not reduced when treated with Go6976 alone, compared to the control at the utilized concentrations. When cytostasis is induced with SN38, the addition of 100 nM Go6976 to halted MDA-MB-231 cells leads to a significant reduction in the number of viable cells by 96 hours[2]. | ||
| 作用机制 | Gö6976 is an ATP-competitive inhibitor. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.64mL 0.53mL 0.26mL |
13.21mL 2.64mL 1.32mL |
26.43mL 5.29mL 2.64mL |
