Regorafenib HCl

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Chemical Structure| 835621-07-3 同义名 : BAY 73-4506 hydrochloride; Stivarga
CAS号 : 835621-07-3
货号 : A481225
分子式 : C21H16Cl2F4N4O3
纯度 : 98%
分子量 : 519.28
MDL号 : -
存储条件：

Pure form Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：

IP 2% DMSO+2% Tween80+40% PEG300+water 5 mg/mL clear

PO 0.5% CMC-Na 53 mg/mL suspension

生物活性
描述 Regorafenib Hydrochloride (BAY 73-4506 hydrochloride) is a multi-target inhibitor of VEGFR1/2/3, PDGFRβ, Kit, RET, and Raf-1, with IC50 values of 13/4.2/46, 22, 7, 1.5, and 2.5 nM, respectively[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.93mL

0.39mL

0.19mL

9.63mL

1.93mL

0.96mL

19.26mL

3.85mL

1.93mL
参考文献

[1]Wilhelm SM, et al. Regorafenib (BAY 73-4506): a new oral multikinase inhibitor of angiogenic, stromal and oncogenic receptor tyrosine kinases with potent preclinical antitumor activity. Int J Cancer, 2011, 129(1), 245-255.

[2]Carr BI, et al. Fluoro-Sorafenib (Regorafenib) effects on hepatoma cells: growth inhibition, quiescence, and recovery. J Cell Physiol, 2013, 228(2), 292-297.