Ro 41-1049 HCl

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Chemical Structure| 127917-66-2 同义名 : Ro 41-1049 hydrochloride
CAS号 : 127917-66-2
货号 : A480414
分子式 : C12H13ClFN3OS
纯度 : 99%+
分子量 : 301.77
MDL号 : MFCD00900596
存储条件：

Pure form Inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 Ro 41-1049 HCl, a reversible and selective MAO-A inhibitor, exhibits binding in human frontal cortex and placenta membrane preparations with Kd values of 16.5 and 64.4 nM, respectively. It targets a uniform population of high-affinity binding sites for [3H]Ro 41-1049[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.31mL

0.66mL

0.33mL

16.57mL

3.31mL

1.66mL

33.14mL

6.63mL

3.31mL
参考文献

[1]Richards G, Messer J, et al. Up-regulation of the isoenzymes MAO-A and MAO-B in the human basal ganglia and pons in Huntington's disease revealed by quantitative enzyme radioautography. Brain Res. 2011 Jan 25;1370:204-14.

[2]Cesura AM, Bos M, et al. Characterization of the binding of [3H] Ro 41-1049 to the active site of human monoamine oxidase-A. Mol Pharmacol. 1990 Mar;37(3):358-66.