Sodium benzoate

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Chemical Structure| 532-32-1 同义名 : 安息香酸钠
CAS号 : 532-32-1
货号 : A477289
分子式 : C7H5NaO2
纯度 : 98%
分子量 : 144.1
MDL号 : MFCD00012463
存储条件：

Pure form Inert atmosphere, room temperature

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 Sodium benzoate, a D-amino acid oxidase (DAAO) inhibitor, improved cognitive function of early-phase Alzheimer's disease (AD) after 24-week treatment[1]. Sodium benzoate (SB) was well tolerated without evident side effects. Sodium benzoate adjuvant therapy improved symptomatology of patients with clozapine-resistant schizophrenia[2]. SB significantly impaired memory and motor coordination. Moreover, SB decreased reduced GSH (reduced glutathione) and increased the MDA (malondialdehyde) level in the brain significantly. Short-term consumption of SB can impair memory performance and increased brain oxidative stress in mice[3]. Repeated administration of sodium benzoate (400 and 800 mg/kg i.p.) and sulfasalazine (500 mg/kg orally) for 7 days, i.e. 2 days before and continued for 5 days after acetic acid infusion, significantly attenuated macroscopic damage and disease activity score as compared to disease control[4].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

6.94mL

1.39mL

0.69mL

34.70mL

6.94mL

3.47mL

69.40mL

13.88mL

6.94mL
参考文献

[1]Lin CH, Chen PK, Wang SH, Lane HY. Sodium benzoate for the treatment of behavioral and psychological symptoms of dementia (BPSD): A randomized, double-blind, placebo-controlled, 6-week trial. J Psychopharmacol. 2019;33(8):1030-1033

[2]Lin CH, Lin CH, Chang YC, et al. Sodium Benzoate, a D-Amino Acid Oxidase Inhibitor, Added to Clozapine for the Treatment of Schizophrenia: A Randomized, Double-Blind, Placebo-Controlled Trial. Biol Psychiatry. 2018;84(6):422-432

[3]Khoshnoud MJ, Siavashpour A, Bakhshizadeh M, Rashedinia M. Effects of sodium benzoate, a commonly used food preservative, on learning, memory, and oxidative stress in brain of mice. J Biochem Mol Toxicol. 2018;32(2):10.1002/jbt.22022

[4]Walia D, Kaur G, Jaggi AS, Bali A. Exploring the therapeutic potential of sodium benzoate in acetic acid-induced ulcerative colitis in rats. J Basic Clin Physiol Pharmacol. 2019;30(5):/j/jbcpp.2019.30.issue-5/jbcpp-2019-0086/jbcpp- 2019-0086.xml.