Inosine Pranobex
产品说明书
 |
同义名 : | Isoprinosine; Imunovir; NPT 10381; NP 113; Immunovir; Groprinosin; Delimmun |
| CAS号 : | 36703-88-5 | |
| 货号 : | A470576 | |
| 分子式 : | C52H78N10O17 | |
| 纯度 : | 98% | |
| 分子量 : | 1115.23 | |
| MDL号 : | MFCD05662374 | |
| 存储条件： |
Pure form Inert atmosphere, room temperature In solvent -20°C:3-6个月-80°C:12个月 |
|
| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Isoprinosine (Inos) or immunovir is a synthetic purine derivative with immune-modulatory and antiviral properties. The drug shows apparent in vivo enhancement of host immune responses by inducing pro-inflammatory cytokines and rapid proliferation of T-cell subsets[1]. Low doses, 50 microgram/kg to 50 mg/kg, significantly increased the numbers of IgM- or IgG-spleen antibody-forming cells. Large doses, such as the LD50 (5 g/kg) or pretreatments where unable to impair mouse immune responsiveness. Isoprinosine (< 500 mg/kg/day) orally administered at time of or one day after immunization stimulated immune responses[2]. In vitro isoprinosine strongly increased T-cell mitogenesis in spleen cells from normal rats, with only modest increases in B-cell mitogenesis and no effects on unstimulated cells. In vivo isoprinosine (50 mg kg-1 day-1 orally) had no effects on spleen cell responsiveness when administered to normal rats for 4 or 14 days. In rats with adjuvant arthritis treated with isoprinosine for 14 days, depressed T-cell responsiveness was completely restored to the level of the nonarthritic animals. T-suppressor cell function, impaired in arthritic rats, was not restored by treatment with isoprinosine[3]. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT00000699 | HIV Infections | Phase 1 | Completed | - | United States, District of Col... 展开 >>umbia George Washington Univ Med Ctr Washington, District of Columbia, United States, 20037 收起 << |
| NCT00002295 | HIV Infections | Not Applicable | Completed | - | United States, California ... 展开 >> Newport Pharmaceuticals International Inc Laguna Hills, California, United States, 92656 收起 << |
| NCT00002061 | Lymphatic Disease ... 展开 >> HIV Infections 收起 << | Not Applicable | Completed | - | United States, California ... 展开 >> Newport Pharmaceuticals International Inc Laguna Hills, California, United States, 92656 收起 << |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
0.90mL 0.18mL 0.09mL |
4.48mL 0.90mL 0.45mL |
8.97mL 1.79mL 0.90mL |
| 参考文献 |
|---|