PT-2385

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Chemical Structure| 1672665-49-4 同义名 : -
CAS号 : 1672665-49-4
货号 : A468981
分子式 : C17H12F3NO4S
纯度 : 99%+
分子量 : 383.34
MDL号 : MFCD28963916
存储条件：

Pure form Sealed in dry, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 PT-2385 is a selective inhibitor of HIF-2α, with a Ki value of less than 50 nM[1][2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.61mL

0.52mL

0.26mL

13.04mL

2.61mL

1.30mL

26.09mL

5.22mL

2.61mL
参考文献

[1]Eli Wallace, Ph.D. PT2385: HIF-2α Antagonist for the Treatment of VHL Mutant ccRCC. 12th International VHL Medical Symposium April 8, 2016.

[2]Xie C, et al. Activation of intestinal hypoxia-inducible factor 2α during obesity contributes to hepatic steatosis. Nat Med. 2017 Nov;23(11):1298-1308.

[3]Wallace EM, et al. A Small-Molecule Antagonist of HIF2α Is Efficacious in Preclinical Models of Renal Cell Carcinoma. Cancer Res. 2016 Sep 15;76(18):5491-500.