Norgestimate

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Chemical Structure| 35189-28-7 同义名 : 炔诺肟酯 ;Dexnorgestrel acetime; RWJ 10131; Norgestimate, Norgestrel oxime acetate, Dexnorgestrel acetime, ORF-10131, D 138, AC-655, RWJ-10131; ORF 10131
CAS号 : 35189-28-7
货号 : A462083
分子式 : C23H31NO3
纯度 : 98+%
分子量 : 369.5
MDL号 : MFCD00867874
存储条件:

Pure form Inert atmosphere, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月

溶解度 : -
动物实验配方:
生物活性
描述 Norgestimate is a steroidal progestin of the 19-nortestosterone group that is used in combination with ethinylestradiol as an oral contraceptive and in combination with estradiol in menopausal hormone replacement therapy.
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02820311 Cardiac Repolarization in Heal... 展开 >>thy Subjects 收起 << Phase 1 Completed - United States, Arizona ... 展开 >> Celerion Tempe, Arizona, United States, 85283 收起 <<
NCT02833831 Healthy Phase 1 Completed - United States, Arizona ... 展开 >> Tempe, Arizona, United States 收起 <<
NCT01537887 Healthy Volunteers Phase 1 Completed - United States, Florida ... 展开 >> For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Daytona Beach, Florida, United States, 32117 United States, Indiana For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. Evansville, Indiana, United States, 47710 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.71mL

0.54mL

0.27mL

13.53mL

2.71mL

1.35mL

27.06mL

5.41mL

2.71mL

参考文献

[1]Chapdelaine A, Desmarais JL, Derman RJ. Clinical evidence of the minimal androgenic activity of norgestimate. Int J Fertil. 1989 Sep-Oct;34(5):347-52.

[2]Anderson FD. Selectivity and minimal androgenicity of norgestimate in monophasic and triphasic oral contraceptives. Acta Obstet Gynecol Scand Suppl.1992;156:15-21.