生物活性 | |||
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描述 | A-674563 is a potent selective Akt1 inhibitor with an IC50 of 14 nM. It also shows inhibitory activity against PKA and CDK2 with IC50 of 16 and 46 nM, respectively. |
细胞研究 | |||||
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细胞系 | 浓度 | 检测类型 | 检测时间 | 活性说明 | 数据源 |
MIA PaCa cells | Cytotoxic assay | Cytotoxicity against human MIA PaCa cells by MTT assay, EC50=0.64 μM | 17523610 | ||
MiaPaCa2 cell | Proliferation assay | Antiproliferative activity against human MiaPaCa2 cell line, EC50=0.4 μM | 16678413 |
实验方案 | |||
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1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
2.79mL 0.56mL 0.28mL |
13.95mL 2.79mL 1.39mL |
27.90mL 5.58mL 2.79mL |
参考文献 |
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