A-674563

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Chemical Structure| 552325-73-2 同义名 : -
CAS号 : 552325-73-2
货号 : A460717
分子式 : C22H22N4O
纯度 : 99%
分子量 : 358.44
MDL号 : MFCD18711680
存储条件:

Pure form Keep in dark place, sealed in dry, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月

溶解度 : -
动物实验配方:
生物活性
描述 A-674563 is a potent selective Akt1 inhibitor with an IC50 of 14 nM. It also shows inhibitory activity against PKA and CDK2 with IC50 of 16 and 46 nM, respectively.
细胞研究
细胞系 浓度 检测类型 检测时间 活性说明 数据源
MIA PaCa cells Cytotoxic assay Cytotoxicity against human MIA PaCa cells by MTT assay, EC50=0.64 μM 17523610
MiaPaCa2 cell Proliferation assay Antiproliferative activity against human MiaPaCa2 cell line, EC50=0.4 μM 16678413
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.79mL

0.56mL

0.28mL

13.95mL

2.79mL

1.39mL

27.90mL

5.58mL

2.79mL

参考文献

[1]Okuzumi T, Ducker GS, et al. Synthesis and evaluation of indazole based analog sensitive Akt inhibitors. Mol Biosyst. 2010 Aug;6(8):1389-402.

[2]Luo Y, Shoemaker AR, et al. Potent and selective inhibitors of Akt kinases slow the progress of tumors in vivo. Mol Cancer Ther. 2005 Jun;4(6):977-86.