ICA-27243
产品说明书
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同义名 : | - |
| CAS号 : | 325457-89-4 | |
| 货号 : | A458603 | |
| 分子式 : | C12H7ClF2N2O | |
| 纯度 : | 95% | |
| 分子量 : | 268.65 | |
| MDL号 : | MFCD17166959 | |
| 存储条件： |
Pure form Inert atmosphere, 2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | ICA-27243 is a selective, potent and orally active KCNQ2/Q3 potassium channel opener with an EC50 value of 0.38 μM. ICA-27243 is less effective in activating KCNQ4 and KCNQ3/Q5. ICA-27243 exhibits antiepileptic and anticonvulsant effects[1][2]. In SH-SY5Y human neuroblastoma cells, ICA-27243 produces membrane potential hyperpolarisation, which is prevented in combination with the M-current inhibitors XE-991 and Linopirdine. In CHO cells stably expressing heterotrimeric KCNQ2/Q3 channels, ICA-27243 enhanced 86Rb+ efflux (EC50=0.2 μM) and whole-cell currents (EC50=0.4 μM). Activation of KCNQ2/Q3 channels was associated with a voltage-dependent hyperpolarising shift in channel activation (V1/2 shifted to -19 mV at 10 μM)[1]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
3.72mL 0.74mL 0.37mL |
18.61mL 3.72mL 1.86mL |
37.22mL 7.44mL 3.72mL |
