Alvespimycin HCl

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Chemical Structure| 467214-21-7 同义名 : Alvespimycin盐酸盐 ;17-DMAG hydrochloride; KOS-1022; BMS 826476; Alvespimycin hydrochloride; KOS-1022 hydrochloride
CAS号 : 467214-21-7
货号 : A452621
分子式 : C32H49ClN4O8
纯度 : 98+%
分子量 : 653.21
MDL号 : MFCD09026908
存储条件：

Pure form Inert atmosphere, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 Alvespimycin hydrochloride is a potent, water-soluble HSP90 inhibitor with IC50 of 62 nM.
细胞研究
细胞系 浓度 检测类型 检测时间 活性说明 数据源
human A2058 cells Cytotoxic assay Cytotoxicity against human A2058 cells by MTT assay, IC50=2.1 nM 18929486
human A2058 cells Function assay Inhibition of Hsp90 in human A2058 cells, EC50=7.9 nM 18929486
human A231 cells Proliferation assay 48 h Antiproliferative activity against human A231 cells after 48 hrs by MTT assay, IC50=0.17 μM 24763261
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.53mL

0.31mL

0.15mL

7.65mL

1.53mL

0.77mL

15.31mL

3.06mL

1.53mL
参考文献

[1]Lang SA, Klein D, et al. Inhibition of heat shock protein 90 impairs epidermal growth factor-mediated signaling in gastric cancer cells and reduces tumor growth and vascularization in vivo. Mol Cancer Ther. 2007 Mar;6(3):1123-32.

[2]Ge J, Normant E, et al. Design, synthesis, and biological evaluation of hydroquinone derivatives of 17-amino-17-demethoxygeldanamycin as potent, water-soluble inhibitors of Hsp90. J Med Chem. 2006 Jul 27;49(15):4606-15.