Secnidazole
产品说明书
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同义名 : | PM-185184; RP-14539 |
| CAS号 : | 3366-95-8 | |
| 货号 : | A445585 | |
| 分子式 : | C7H11N3O3 | |
| 纯度 : | 95% | |
| 分子量 : | 185.18 | |
| MDL号 : | MFCD00864656 | |
| 存储条件： |
Pure form Inert atmosphere, room temperature In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Secnidazole, a 5-nitroimidazole with a longer half-life, is structurally related to metronidazole and tinidazole. For treatment of bacterial vaginosis (BV), secnidazole is a suitable single-dose oral drug having a longer serum half-life than metronidazole. The MIC90 (μg/mL) for secnidazole was similar to metronidazole and tinidazole for Anaerococcus tetradius (secnidazole: MIC90 2; metronidazole: MIC90 2; tinidazole: MIC90 4), Atopobium vaginae (32; >128; 128), Bacteroides species (2; 2; 2), Finegoldia magna (2; 2; 4), Gardnerella vaginalis (128; 64; 32), Mageeibacillus indolicus (2; 2; 2), Megasphaera-like bacteria (0.5; 0.25; 0.5), Mobiluncus curtisii (128; >128; >128) and Mobiluncus mulieris (>128; >128; >128), Peptoniphilus lacrimalis (4; 4; 4) and Peptoniphilus harei (2; 2; 4), Porphyromonas species (0.25; 0.5; 0.25), Prevotella bivia (8; 8; 8), Prevotella amnii (2; 1; 2) and Prevotella timonensis (2; 2; 2). The MIC90 for all lactobacilli tested was >128 μg/mL for secnidazole, metronidazole and tinidazole[3]. The clinical cure rate, microbiological effect and the therapeutic cure rate of 2 g secnidazole was significantly more than that of 1 g secnidazole[4]. Secnidazole is an effective and easily administered drug for the treatment of clinical canine giardiosis. Giardiosis resolved in all 14 patients in Group A within 13 days following a single oral dose of secnidazole (30 mg/kg). For the young puppies in Group B, giardiosis was reduced by 90% (9/10) within 22 days following two consecutive doses of secnidazole (30 mg/kg; 2 weeks apart)[5]. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT01019083 | Cholera Typho... 展开 >>id 收起 << | Phase 1 Phase 2 | Completed | - | Bangladesh ... 展开 >> Firdausi Qadri Dhaka, Bangladesh, 1212 收起 << |
| NCT00607074 | Giardiasis | Not Applicable | Completed | - | Bangladesh ... 展开 >> National Institute of Preventive and Social Medicine Mohakhali, Dhaka, Bangladesh, 1212 收起 << |
| NCT01733966 | Diverticular Sigmoïditis | Phase 3 | Terminated(difficulties to rec... 展开 >>ruit patients who suffer from this pathology) 收起 << | - | - |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
5.40mL 1.08mL 0.54mL |
27.00mL 5.40mL 2.70mL |
54.00mL 10.80mL 5.40mL |
| 参考文献 |
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