同义名 :	(±)-BGB-3111
	CAS号 :	1633350-06-7
	货号 :	A444177
	分子式 :	C27H29N5O3
	纯度 :	99%+
	分子量 :	471.55
	MDL号 :	MFCD30738015
	存储条件：	Pure form Sealed in dry, 2-8°C In solvent -20°C:3-6个月-80°C:12个月
	溶解度 :	-
	动物实验配方：

生物活性

描述

(±)-Zanubrutinib, also known as (±)-BGB-3111, is an efficacious, selective, oral Btk inhibitor that exhibits nanomolar-level Btk inhibitory activity. In various MCL and DLBCL cell lines, (±)-Zanubrutinib inhibits BCR-triggered autophosphorylation of Btk, blocks downstream PLC-γ2 signaling, and effectively suppresses cell proliferation. Compared to PCI-32765, (±)-Zanubrutinib demonstrates more restricted off-target activity against a panel of kinases, including ITK[1].

实验方案
	1mg	5mg	10mg
1 mM 5 mM 10 mM	2.12mL 0.42mL 0.21mL	10.60mL 2.12mL 1.06mL	21.21mL 4.24mL 2.12mL

参考文献
[1]Wu J, Zhang M, Liu D. Bruton tyrosine kinase inhibitor ONO/GS-4059: from bench to bedside. Oncotarget. 2017 Jan 24;8(4):7201-7207. [2]Wu J, Liu C, Tsui ST, Liu D. Second-generation inhibitors of Bruton tyrosine kinase. J Hematol Oncol. 2016 Sep 2;9(1):80.