同义名 :	SM-3997
	CAS号 :	87760-53-0
	货号 :	A437039
	分子式 :	C21H29N5O2
	纯度 :	97%
	分子量 :	383.49
	MDL号 :	MFCD00904852
	存储条件：	Pure form Sealed in dry, 2-8°C In solvent -20°C:3-6个月-80°C:12个月
	溶解度 :	-
	动物实验配方：

生物活性
描述	Tandospirone (SM-3997) is a potent and selective partial agonist of the 5-HT1A receptor, with a Ki of 27 nM, exhibiting anxiolytic and antidepressant properties. It is explored for its applications in central nervous system disorders and their mechanisms[1][2][3].

临床研究
NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT03667677	Hypertension ... 展开 >>Anxiety 收起 <<	Phase 4	Not yet recruiting	July 1, 2020	China, Beijing ... 展开 >> Beijing Friendship Hospital of Capital Medical University Beijing, Beijing, China Beijing Haidian Section of Peking University Third Hospital Beijing, Beijing, China Xuanwu Hospital of Capital Medical University Beijing, Beijing, China China, Chongqing Yongchuan Hospital of Chongqing Medical University Chongqing, Chongqing, China China, Giangsu Zhongda Hospital of Southeast University Nanjing, Giangsu, China China, Hebei Kailuan General Hospital Tangshan, Hebei, China China, Shanxi the First Affiliated Hospital of Shanxi Medical University Taiyuan, Shanxi, China 收起 <<
NCT01614041	Generalized Anxiety Disorder	Phase 4	Unknown	December 2017	China ... 展开 >> Shanghai Tongji Hospital Recruiting Shanghai, China, 200065 Contact: Wenyuan Wu, MD 收起 <<
NCT03151382	Alzheimer Disease ... 展开 >> Cognitive Function 收起 <<	Phase 4	Not yet recruiting	June 30, 2018	-

实验方案
	1mg	5mg	10mg
1 mM 5 mM 10 mM	2.61mL 0.52mL 0.26mL	13.04mL 2.61mL 1.30mL	26.08mL 5.22mL 2.61mL

参考文献

[1]Hamik A, et al. Analysis of tandospirone (SM-3997) interactions with neurotransmitter receptor binding sites. Biol Psychiatry. 1990 Jul 15;28(2):99-109. [2]Xuefei Huang, et al. Role of tandospirone, a 5-HT1A receptor partial agonist, in the treatment of central nervous system disorders and the underlying mechanisms. Oncotarget. 2017 Nov 24; 8(60): 102705–102720. [3]Kyoko Nishitsuji, et al. The pharmacokinetics and pharmacodynamics of tandospirone in rats exposed to conditioned fear stress. Eur Neuropsychopharmacol. 2006 Jul;16(5):376-82.