(S)-Mephenytoin

产品说明书

Print
Chemical Structure| 70989-04-7 同义名 : (S)-5-ethyl-3-methyl-5-Phenylhydantoin; (+)-Mephenytoin
CAS号 : 70989-04-7
货号 : A435923
分子式 : C12H14N2O2
纯度 : 99%+
分子量 : 218.25
MDL号 : MFCD00270025
存储条件:

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月

溶解度 : -
动物实验配方:
生物活性
描述 (S)-Mephenytoin, the (+)-enantiomer of Mephenytoin, also serves as an anticonvulsive agent. It is a specific substrate for the cytochrome P450 enzyme CYP2C19 and is utilized in pharmacokinetic studies to analyze cytochrome P450 metabolism[1].[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

4.58mL

0.92mL

0.46mL

22.91mL

4.58mL

2.29mL

45.82mL

9.16mL

4.58mL

参考文献

[1]Shimada T, et, al. Human liver microsomal cytochrome P-450 mephenytoin 4-hydroxylase, a prototype of genetic polymorphism in oxidative drug metabolism. Purification and characterization of two similar forms involved in the reaction. J Biol Chem. 1986 Jan 15;261(2):909-21.

[2]Goldstein JA, et, al. Evidence that CYP2C19 is the major (S)-mephenytoin 4'-hydroxylase in humans. Biochemistry. 1994 Feb 22;33(7):1743-52.