MM-102 TFA

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Chemical Structure| 1883545-52-5 同义名 : HMTase Inhibitor IX TFA
CAS号 : 1883545-52-5
货号 : A435102
分子式 : C37H50F5N7O6
纯度 : 99%
分子量 : 783.83
MDL号 : MFCD29472272
存储条件：

Pure form Keep in dark place, inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 MM-102 trifluoroacetate is a potent WDR5/mLL interaction inhibitor, achieves IC50 = 2.4 nM with an estimated Ki < 1 nM in WDR5 binding assay, which is > 200 times more potent than the ARA peptide.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.28mL

0.26mL

0.13mL

6.38mL

1.28mL

0.64mL

12.76mL

2.55mL

1.28mL
参考文献

[1]Karatas H, Townsend EC, et al. High-affinity, small-molecule peptidomimetic inhibitors of MLL1/WDR5 protein-protein interaction. J Am Chem Soc. 2013 Jan 16;135(2):669-682.