Mavatrep

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Chemical Structure| 956274-94-5 同义名 : JNJ-39439335
CAS号 : 956274-94-5
货号 : A433469
分子式 : C25H21F3N2O
纯度 : 99%
分子量 : 422.44
MDL号 : MFCD28502099
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 Mavatrep is an orally bioavailable TRPV1 antagonist (Ki=6.5 nM), exhibits minimal effect on the enzymatic activity (IC50 > 25 μM) of CYP isoforms 3A4, 1A2, and 2D6.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.37mL

0.47mL

0.24mL

11.84mL

2.37mL

1.18mL

23.67mL

4.73mL

2.37mL
参考文献

[1]Parsons WH, Calvo RR, et al. Benzo[d] imidazole Transient Receptor Potential Vanilloid 1 Antagonists for the Treatment of Pain: Discovery of trans-2-(2-{2-[2-(4-Trifluoromethyl-phenyl)-vinyl] -1H-benzimidazol-5-yl}-phenyl)- propan-2-ol (Mavatrep). J Med Chem. 2015 May 14;58(9):3859-74.