SU4312

产品说明书

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Chemical Structure| 5812-07-7 同义名 : NSC 86429
CAS号 : 5812-07-7
货号 : A431504
分子式 : C17H16N2O
纯度 : 98%
分子量 : 264.32
MDL号 : MFCD00224096
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 SU 4312 is a potent and selective inhibitor of VEGFR and PDGFR tyrosine kinases (IC50 values are 0.8 and 19.4 μM respectively), which is selective over EGFR and c-Src tyrosine kinases.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.78mL

0.76mL

0.38mL

18.92mL

3.78mL

1.89mL

37.83mL

7.57mL

3.78mL
参考文献

[1]Guo B, Hu S, et al. Substantial protection against MPTP-associated Parkinson's neurotoxicity in vitro and in vivo by anti-cancer agent SU4312 via activation of MEF2D and inhibition of MAO-B. Neuropharmacology. 2017 Aug 11. pii: S0028-3908(17)30381-7.

[2]Cui W, Zhang Z, et al. The anti-cancer agent SU4312 unexpectedly protects against MPP(+) -induced neurotoxicity via selective and direct inhibition of neuronal NOS. Br J Pharmacol. 2013 Mar;168(5):1201-14.