Nomifensine maleate
产品说明书
 |
同义名 : | (±)-Nomifensine maleat |
| CAS号 : | 32795-47-4 | |
| 货号 : | A428762 | |
| 分子式 : | C20H22N2O4 | |
| 纯度 : | 98% | |
| 分子量 : | 354.4 | |
| MDL号 : | MFCD00069320 | |
| 存储条件： |
Pure form Sealed in dry, room temperature In solvent -20°C:3-6个月-80°C:12个月 |
|
| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Nomifensine Maleate (Nomifensine) is an isoquinoline antidepressant that inhibits the reuptake of dopamine at central synapses. It also inhibits norepinephrine reuptake but is only a weak inhibitor of 5-hydroxytryptamine[3]. Nomifensine is a safe and effective antidepressant with a fairly unique pharmacological profile[4]. Short-term use of nomifensine was relatively free from side effects and was remarkably effective in the treatment of ADD(attention deficit disorder)-RT(residual type)[5]. Nomifensine and some of its structural analogues produce behavioral effects indicative of indirect dopaminergic agonist properties, such as hyperlocomotion. Both PTIQ (nomifensine analogue 4-phenyl-1,2,3,4-tetrahydroisoquinoline) and nomifensine significantly augmented METH-induced stereotypical behavior and locomotion in mice[6]. Nomifensine elevates the tone of rapid dopamine signals in the brain[7]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
2.82mL 0.56mL 0.28mL |
14.11mL 2.82mL 1.41mL |
28.22mL 5.64mL 2.82mL |
| 参考文献 |
|---|