![]() |
同义名 : | VX-944 |
CAS号 : | 297730-17-7 | |
货号 : | A428299 | |
分子式 : | C25H27N5O5 | |
纯度 : | 99%+ | |
分子量 : | 477.51 | |
MDL号 : | MFCD22200574 | |
存储条件: |
Pure form Sealed in dry, 2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
|
溶解度 : | - | |
动物实验配方: |
生物活性 | |||
---|---|---|---|
描述 | AVN-944 (also known as VX-944) is an orally active, potent, selective, noncompetitive, and specific inhibitor of IMPDH (inosine monophosphate dehydrogenase). IMPDH is an essential rate-limiting enzyme in de novo guanine nucleotide synthesis. Additionally, AVN-944 acts as an inhibitor of arenavirus RNA synthesis, blocking arenavirus infection. It exhibits broad anti-cancer activities and is applicable to research on multiple myeloma (MM) and acute myeloid leukemia (AML) [1][2][3]. |
实验方案 | |||
---|---|---|---|
1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
2.09mL 0.42mL 0.21mL |
10.47mL 2.09mL 1.05mL |
20.94mL 4.19mL 2.09mL |
参考文献 |
---|