SJB3-019A

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Chemical Structure| 2070015-29-9 同义名 : -
CAS号 : 2070015-29-9
货号 : A426930
分子式 : C16H8N2O3
纯度 : 99%+
分子量 : 276.25
MDL号 : MFCD26960956
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 SJB3-019A, with an IC50 of 0.0781 μM, exhibits five times the potency of SJB2-043 in enhancing ID1 degradation and inducing cytotoxicity in K562 cells. This compound increases the levels of ubiquitinated FANCD2 and PCNA while reducing homologous recombination (HR) activity, highlighting its potential in cancer therapy[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.62mL

0.72mL

0.36mL

18.10mL

3.62mL

1.81mL

36.20mL

7.24mL

3.62mL
参考文献

[1]Helena Mistry, et al. Small molecule inhibitors of USP1 target ID1 degradation in leukemic cells. Mol Cancer Ther Published OnlineFirst October 15, 2013.